SS-31 (10mg)
A high-purity, lyophilized synthetic mitochondria-targeting tetrapeptide, also known in research literature as Elamipretide or MTP-131. It is strictly characterized for advanced laboratory applications involving stabilization of the inner mitochondrial membrane, cardiolipin binding, optimization of the electron transport chain (ETC), and attenuation of pathological oxidative stress.
Trust & Quality Verification
- Research Use Only. Not for human or veterinary use.
- 99% Purity Replacement Guarantee
- Verifiable purity via HPLC & Mass Spectrometry
- Supplied as lyophilized powder for stability during transport and storage
- Certificate of Analysis (COA) available per lot
- Safety Data Sheet (SDS) available
Description
SS-31 (Elamipretide) is a synthetic, cell-permeable tetrapeptide belonging to the Szeto-Schiller (SS) family of aromatic-cationic peptides. Unlike conventional antioxidants that indiscriminately scavenge reactive oxygen species (ROS) throughout the cell, SS-31 selectively concentrates within the inner mitochondrial membrane (IMM).
Due to its alternating aromatic and cationic amino acid motif, it crosses the plasma and outer mitochondrial membranes in an energy-independent manner, independent of the mitochondrial membrane potential.
In experimental pharmacology and bioenergetic research, SS-31 serves as a highly targeted chemical probe. It binds specifically to cardiolipin, a unique and critical phospholipid exclusively expressed on the inner mitochondrial membrane. By anchoring to cardiolipin, SS-31 stabilizes cristae architecture, promotes the efficient assembly of respiratory supercomplexes, and prevents the pathological opening of the mitochondrial permeability transition pore (mPTP) during severe cellular stress events, such as ischemia-reperfusion (I/R) injury and neurodegeneration.
Biochemical Characteristics
Chemically, SS-31 is engineered with modified, non-naturally occurring amino acids to ensure absolute resistance to rapid proteolytic degradation while maintaining a highly specific binding affinity for anionic lipid bilayers.
- Sequence/Structure: Tetrapeptide; D-Arg-Dmt-Lys-Phe-NH2 (where Dmt represents 2,6-dimethyltyrosine).
- Permeability: Possesses a net charge of +3 at physiological pH, allowing it to efficiently penetrate cell membranes while selectively accumulating (1000- to 5000-fold) at the cardiolipin-rich inner mitochondrial membrane.
- Stability: Supplied as a lyophilized salt to ensure structural integrity. The inclusion of D-arginine protects the peptide from aminopeptidase cleavage, radically extending its experimental half-life in physiological assays.
- Specificity: Selectively prevents pathological ROS generation directly at the source (Complex I and III of the ETC) without disrupting the necessary physiological redox signaling required for healthy cellular homeostasis.
Chemical Properties
| Property | Specification |
| Molecule Name | SS-31 |
| Synonyms | Elamipretide; Bendavia; MTP-131; RX-31 |
| PubChem CID | 11764719 |
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | 639.8 g/mol |
| Form | Lyophilized Powder |
| Purity | ≥99% (Verified via HPLC) |
| Solubility | Soluble in water and aqueous buffers (refer to SDS) |
| Documentation | COA available per lot; SDS available |
- Stable at room temperature for up to 90 days. For long-term storage, keep at -20°C (-4°F) or colder.
- Once mixed with a solvent (e.g., bacteriostatic water), the solution must be stored at 4 °C (39°F) and utilized within 30 days. Avoid repeated freeze-thaw cycles, as this degrades the peptide structure.
RESEARCH USE ONLY
This product is intended strictly for laboratory research use only. It is not for human or veterinary use. It is not intended for diagnosis, treatment, cure, or prevention of any disease. All purchases are subject to our Terms of Service and Purity Guarantee.
No COAs available for this product.
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